Neurodegenerative Diseases: Current Research

The Protecting Effects of Antidiabetic Drug in Kainate Induced Lobe Encephalopathy

Szekler Hobson

Department of Medicine, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, MA, USA

Abstract

Introduction: Antidiabetic, the foremost ordinarily prescribed antidiabetic, has been shown to be effective in dominant seizures in some studies. However, there square measure some reports of proconvulsant activity of antidiabetic in diabetic patients. The aim of this study was to analyze the consequences of antidiabetic dose on anti-seizure and neuronic protecting activity.

Methods: Male Wistar rats were arbitrarily divided into five teams as follows: 1-control/vehicle cluster, 2-Kainic acid (KA), 3-metformin+KA (50 mg/kg), 4-metformin+KA (100 mg/kg), 5-metformin KA (200 mg/kg). Lobe encephalopathy (TLE) was induced by injection of 0.5 five mineral into the left ventricle. Metformin was administered orally for 2 weeks before the induction of TLE.

Results: We have a tendency to found that antidiabetic at higher doses (100 and two hundred mg/kg) considerably suppressed the progression of seizure in TLE and ameliorated the neuronic loss within the hippocampus induced by Hindu deity. However, the low dose of antidiabetic had no result.

Conclusion: We have a tendency to ended that antidiabetic is also a possible agent for the treatment of encephalopathy and seizure and this result is dose-dependent.

Keywords:

Metformin; Epilepsy; Dose dependent; Neuroprotection; Medication